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Alzheimer's Disease and Other Dementia's May Be Slowed Down By Caffeine

Posted May 23 2010 5:22pm





Caffeine one of the most consumed beverages in the world. It has possible helpful effect for preservation of proper brain functioning. As of late it has been appropriately appreciated. Considerable findings from epidemiological studies and basic research in animal models proposes that caffeine could be vigilant against decline in cognitive function witnessed in dementia and Alzheimer's disease. A special supplement of the Journal Of Alzheimer's Disease, “Therapeutic opporutnites for Caffeine in Alzheimer's Disease and Other Nerodegenerative Diseases ”. This gives a new outlook on this topic and presents key findings.

Guest editors Alexandre de Mendonça, Institute of Molecular Medicine and Faculty of Medicine, University of Lisbon, Portugal, and Rodrigo A. Cunha, Center for Neuroscience and Cell Biology of Coimbra and Faculty of Medicine, University of Coimbra, Portugal, have gathered a group of international experts to examine the reactions of caffeine on the brain. The cumulative collection from the original studies indicates several views on topics extending from molecular targets of caffeine, neurophysiology modifications and adaptations to potential mechanisms underlying the behavioral and neuroprotective actions of caffeine in distant brain pathologies.

Guest editors Mendonca and Cunha stated the epidemiological studies at first showed an opposite affiliation between the constant drinking of caffeine and the extent of Parkinson's Disease. It was similar to animal studies of Parkinson's Disease showing that caffeine stopped motor deficits along with nerodegeneration. Following a few epidemiological studies showed that consuming moderate amounts of caffeine was contrarily associated with cognitive degeneration associated with aging along with the extent of Alzheimer's Disease. This was paralleled by animal studies showing that continuous
caffeine administration stopped memory deterioration and nerodegeneration in animal models of aging and Alzheimer's Disease.

The main findings presented at the Therapeutic Opporutnites for Caffeine in Alzheimer's Disease and other Nerodegenerative Diseases were as follows:

Numerous beneficial effects of caffeine to normalize brain functioning and prevent degeneration.
Caffeine's neuroprotective profile and ability to decrease amyloid-beta production.
Caffeine as a possible choice as a disease modifying agent for Alzheimer's disease.
Definite impact of caffeine on cognition and memory performance.
Identification of adenosine A2A receptors as the main target for neuroprotection afforded by caffeine consumption.
Confirming data by valuable meta-analysis.
Epidemiological studies authenticated by meta-analysis advocating that caffeine could be protective against Parkinson's disease.
A few methodological concerns must be solved before moving forward to assured clinical trials.

Mendonca and Cunha also mentioned that daily follow ups with Alzheimer's Disease has educated us that by improving daily living it could become more of a significant marker of amelioration than the little improvements in objective measures of memory performance. One of the main significant complication of Alzheimer's Disease is depression in mood and the current observations of caffeine could become a good mood normalizer are of distinct interest.

There are some alternative therapies for treating Alzheimer's Disease:

Naturopathy i ncludes supplementing antioxidant vitamins (a,e,c) in the patients diet along with adding carotenois, selenium, zinc and thiamin. Botanical supplements have been noted to improve cognitive function.

Music therapy has been known to calm down agitated patients with Alzheimer's by improving their mood and enhancing their long term memory.

Homeopathic medicines
such as Alumina for persons who are very moody or sad, great mental confusion . Cordyceps which is made from Caterpillar fungus which is Tibetan mushroom. It boots energy and stamina. Genko Biloba for poor concentration and exhaustion. Among others that homeopathic medicine provides.

Aroma therapy had three studies within the last two years showing major benefits with aromatherapy on advanced agitation in Alzheimer's. 2% of Lavender oil used for daily inhalation and lemon oil used as a hand cream. Studies revealed significant improvement.

Chinese medicine for Alzheimer's currently have two treatments available. Use of herbal formulas based on traditional Chinese medicine and the administration of a alkaloid drug called huperzine. The drug stops the breakdown of the neurotransmitter acetylcholine and allowing more of it to be available for brain functions including memory.

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