Systemic reactions of allergen immunotherapy is a topic of great importance in our field. I have been compelled to write about this topic because of my team leader nurse Erin. Systemic reactions can be simply understood as a reaction to immunotherapy that occurs more than 5 cm beyond the local area where the allergen immunotherapy injection was given. Until recently, the definition and grading of severity has not been well standardized. A Task Force of the AAAAI/ACAAI proposed a draft of recommendations, that was published in March of 2010. I read them and agree with them. Even more instructive were the comments that have been sent it to the publisher's webpage . Once the final guidelines are endorsed by the member societies, I plan to have our operations reviewed to make sure we have minimized the chances of a systemic reaction. Generally immunotherapy has become safer with time . The published abstract of this article is on PubMed here .
My practice has been both fortunate and careful, in that I have had no fatalities related to immunotherapy since I began practicing allergy in 1991. This is a start on this difficult topic.