Health knowledge made personal
Join this community!
› Share page:
Search posts:

Sleep Deprivation May Be Associa ...

Posted Oct 04 2009 10:01pm
Sleep Deprivation May Be Associated With Alzheimer's

Sleep-deprived mice have higher levels of amyloid-β, greater amyloid-β plaque deposition

05 oct 2009-- Sleep deprivation may play a role in the development of Alzheimer's disease, according to research published online Sept. 24 in Science.

Jae-Eun Kang, Ph.D., of Washington University in St. Louis, and colleagues analyzed data from experiments on mice examining the effects of wakefulness, sleep deprivation, and orexin -- a molecule that regulates wakefulness -- on amyloid-β (Aβ) measurements.

The researchers found that in transgenic and wild-type mice, animals had a difference in interstitial fluid Aβ levels between dark and light phases, with higher levels during the dark period, though fluctuations were linked to the sleep-wake cycle rather than to exposure to light or darkness. Mice subjected to sleep deprivation had significantly higher Aβ levels. Infusion of orexin-A -- which induces rodent wakefulness -- was associated with higher Aβ levels. In addition, mice subjected to sleep restriction for 21 days had higher Aβ plaque deposition; however, chronic orexin receptor blockade for two months decreased Aβ plaque formation in amyloid precursor protein transgenic mice in several brain regions compared to controls.

"Sleep is a complex behavioral state whose ultimate functions remain poorly understood. Sleep disturbances, in addition to being prominent in neurodegenerative diseases, could exacerbate a fundamental process leading to neurodegeneration, and optimization of sleep time could potentially inhibit aggregation of toxic proteins and slow the progression of Alzheimer's disease," the authors conclude.

Full Text (subscription or payment may be required)

Post a comment
Write a comment: