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Possible Indicators Discovered for Development of Type2 Diabetes in Women

Posted Sep 14 2009 10:59pm
From Geriatric Pharmacy Intern, Lynda Pardo, PharmD(c)
Palm Beach Atlantic University College of Pharmacy

In a prospective study conducted in Sweden since the late 1960's that was recently published in the FASEB journal, researchers have discovered that the size of a woman's fat cells and/or her waist-to-height ratio can be strong predictors for the development of Type 2 Diabetes. The participants in the study where provided gratuitous healthcare for 25 years, during which investigators obtained adipocytes from the women's abdomen and thighs through biopsies. It was found that the quantity of adipocytes, or fat cells, remained a constant size after the women where in their teens, but grew larger in volume and changed (specifically the abdominal cells) when some of them had developed diabetes. Malin Lonn, co-author of the study says that recognizing women who are at risk for diabetes can also be done by measuring the waist-to-hip ratio. This study could help explain why some women who are not overweight and have a relatively normal waist circumference can still go on to develop diabetes.
It has long been known that obesity can lead to metabolic disorders such as diabetes, but researchers feel that perhaps this discovery can actually help bring about anticipatory procedures in combating, developing, and applying specific therapeutic solutions to this patient population who display no obvious risk factors. Diabetes can be attributed to other risk factors also such as genes, sedentary lifestyle, and race or ethnicity. Also, since many people are now being diagnosed with type 2 diabetes earlier in life, perhaps more studies like this one can further assist in shedding some light on how to search for other causes that continue to contribute to this growing problem.
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