I'm not sure what to tell you about her lower back burning. Perhaps it's a kidney infection or perhaps it's shingles acting up. Or maybe it's muscle pain due to a statin. Or simple muscle injury. Or vertebral compression fracture. The possibilities aren't endless but they're quite varied. Her family physician will need more information.
As for her heart rate of 40, that seems pretty slow, regardless of whether she's taking blood pressure medicine or not. Is she light headed, weak, woozy, or faint? I suspect that she's taking a beta blocker. I'd recommend re-evaluation by her family physician and switching to another medicine or at least lower the dose of the beta blocker so that her heart can beat just wee bit faster, say at least 60bpm.
The swelling in her right ankle might be due to a blood pressure medication, an injury or a clot in her leg known as a DVT, short for deep vein thrombosis. Best to have her evaluated by her family physician to address her conditions and your concerns.
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